B cells blunt neonatal immunity

THE ROLE OF B-CELLS IN THE DEVELOPMENT OF IMMUNITY TO CRYPTOSPORIDIUM INFECTION

Studies have shown that symptomatic improvement of cryptosporidiosis in immunocompromised patients is possible following treatment with" hyperimmune" colostrum containing anti-sporozoite antibodies from cattle immunized with Cryptosporidium parvum antigens. The contribution to immunity of antibodies developed during Cryptosporidium infection is unclear, however. Previously, we showed that ...

B cells and humoral immunity in atherosclerosis.

Insights into the important contribution of inflammation and immune functions in the development and progression of atherosclerosis have greatly improved our understanding of this disease. Although the role of T cells has been extensively studied for decades, only recently has the role of B cells gained more attention. Recent studies have identified differential effects of different B-cell subs...

Inhibition of antitumor immunity by B cells.

In the August issue of Cancer Research , Inoue et al. reported a mechanism by which B cells inhibit the immune response against tumors. Their results support a model whereby B cell stimulation via CD40 leads to diminished CD8 and natural killer cell–mediated IFN-g secretion and thereby attenuates antitumor immunity (1). Their results are in line with findings previously published in 2005 in our...

Formation of B-1 B cells from neonatal B-1 transitional cells exhibits NF-κB redundancy.

The stages of development leading up to the formation of mature B-1 cells have not been identified. As a result, there is no basis for understanding why various genetic defects, and those in the classical or alternative NF-κB pathways in particular, differentially affect the B-1 and B-2 B cell lineages. In this article, we demonstrate that B-1 B cells are generated from transitional cell interm...

Formation of B-1 B Cells from Neonatal B-1 Transitional Cells Exhibits NF-kB Redundancy